The Scofield Mine disaster was a mining explosion that occurred at the Winter Quarters mine in 1900. The mine was located near the town of Scofield, Utah. In terms of life lost it was the worst mining accidents at that point in American history.

On May 1, 1900, a dust explosion in the Winter Quarters Mine killed at least 200 men, with some rescuers placing the death toll as high as 246. Some were killed outright by the explosion, but most died of asphyxiation by white damp and after damp. Death came so quickly that some of the mine workers were found still clutching their tools. It still ranks as one of the worst mining disasters in the United States with a high number of deaths.

The death toll is 200 but there was some confusion about this as one of the bodies was not found until August 1900. Other numbers have been suggested, but little or no evidence is available to support these claims.

One of the deceased had a watch that had stopped at 10:28 AM. The State Mine Inspector's Report determined that a large shot of powder in the Number 4 Section ignited coal dust which spread throughout Number 4 killing some of the miners. The explosion blew up the fan used to ventilate Number 4. However in Number 1 mine which was connected, the fan continued to run and pulled the remnants of the explosion, including afterdamp (primarily carbon monoxide) into Number 1. When the miners inside Number 1 tried to walk out, they walked into the poisonous gas, and were overcome and killed. Many workers were too far into the mine to escape.